The event taking place that weekend is the Indianapolis 8 Hour race, with Palou set to join Lone Star Racing for the Intercontinental GT Challenge taking place on the Saturday.
Although he drives with Honda power in IndyCar, that weekend, Palou will be powered by Mercedes, driving the #4 Mercedes-AMG GT3 car alongside Luca Stolz and Fabian Schiller.
“I’ve done GT racing in the past in Japan, but I would say it’s been more than five years now,” Palou explained.
“I’m extremely excited to be giving it another go.”
Palou will not be the only IndyCar driver in action that weekend, either, with veteran Conor Daly also set to compete.
Daly will drive the #92 BMW M4 GT3 alongside Connor De Phillippi and Kenton Koch.