Max Verstappen will be aiming to make it three wins in succession at the iconic circuit, as he looks to extend his lead over Dutch GP winner Lando Norris at the top of the drivers' championship.
While the on-track action is sure to catch much of the attention of F1 fans, one team have now found themselves thrust into the spotlight.
Alpine employees in show of solidarity
Employees at Alpine will stage a strike on Friday morning amid anger over Renault's plans to stop making Formula 1 engines.
In recent years, Renault - who supply the engines for Alpine - have lacked power in comparison to their rivals, resulting in the French company's chief executive Luca de Meo deciding to go in another direction.
The French carmaker wants to turn its F1 team into an engine customer, with reports suggesting a supply deal with Mercedes is likely.
Approximately 350 staff currently employed at Renault's factory in Viry-Chatillon now face an uncertain future, and are using this weekend's grand prix to make their voices heard.
As reported by The Mirror, the Social and Economic Council - which represents the staff concerned - have confirmed that the majority of those based in France will be involved in the upcoming strike action,
Alpine staff at Monza are also set to show their support by wearing white T-shirts displaying a message of solidarity, as well as a black armband.
The council insists that the planned action will have a bearing on track operations from taking place, meaning Alpine drivers Pierre Gasly and Esteban Ocon will be able to run their practice programmes as normal.