Larson and Suarez came together on a restart as the pair attempted to round turn four three-wide with Brad Keselowski.
The wreck ruined what could have been a fourth win of the Cup Series season for Larson, who won pole for the inaugural running of the Iowa race and looked to have one of the fastest cars in the field on race day.
LARSON & HAMLIN CRASH!
The fastest car of the night looks to be out of contention as contact between the No. 5 and No. 99 sends Larson into Hamlin and the outside wall.
Who was at fault for Kyle Larson and Denny Hamlin's crash?
Hamlin was only a passenger in the incident, the 43-year-old picking the wrong restart to run up high as Larson veered into the side of his Toyota and slammed both into the wall.
Reflecting on the crash, Hamlin was left frustrated: "You feel like with as fast as his [Larson's] car was - and he was that day - did he have to go get two cars right in that corner? Probably not, but that’s hindsight," he told the Actions Detrimental podcast.
"90% of the time it works, and you go on, you’re unscathed and you just gained multiple spots on a restart.
"It’s hard to second guess that for sure if you see a gap and an opening, usually you take it because you don’t think about ‘well this person is likely to misjudge the corner and run into me.’
"Of course, you always have to take into account the people you’re around when you do decide to put yourself in a vulnerable spot. It’s just one of those things where certainly the five team’s banging their heads against the hauler door because they clearly had one of the best if not the best car and got a bad finish out of it.”
Acknowledging the squandered shot at victory, Larson said after the race: "I wish I could have that restart back."
"I guess I could have just not gone to the middle and been more patient with how fast my car was and knowing who I was around,” he added. “I wanted to get as many cars as I could in the beginning of that little run, and it probably ended up biting me.”
“We made it [three-wide] until, I don’t know, the exit of the corner, and then I’m not sure if Suarez got loose underneath me or what happened. He got into my left rear and got me out of control.”
Suarez claimed he was initially not sure who was to blame, but felt the two cars above him on the road were lower than he expected.