Hamilton's departure brings an end to a highly-successful 12-season partnership with the team, with his replacement having huge shoes to fill after the Brit scooped six drivers' championships and helped the team claim eight constructors' titles.
And, rather than opting for an experienced race winner to replace him, Mercedes have elected to put young up-and-coming star Antonelli in the caralongside George Russell for next campaign.
Is Antonelli's F1 career in danger?
Whilst Antonelli has been tipped to do great things in the sport, he has already shown at times this season that the pressure of stepping in to replace Hamilton may not be easy to cope with.
At the Italian Grand Prix, for example, just moments into his first official F1 session in FP1, Antonelli lost control of the Mercedes, crashing into the barriers at Parabolica and bringing out a red flag to mark a disastrous debut outing.