The Mercedes star received a puncture after hitting the debris on the main straight, with Sainz's Ferrari also damaged and both drivers headed into the pits.
A safety car was eventually deployed as a result of the debris, however the damage was already done for Hamilton who dropped all the way down to P16.
Whilst the Brit managed to gain a few places on the re-start, it was not long before another safety car was brought out after Sergio Perez spun and Nico Hulkenberg crashed.
The next re-start saw Hamilton shuffle down the order to P14, sandwiched between the RBs of Liam Lawson and Yuki Tsunoda.
If the evening could not get any worse for Hamilton, the champion was then placed under investigation for speeding in the pitlane.
The FIA slammed the Mercedes star with yet another penalty, this time a drive through which ended his hopes of a points finish.