The Brit won six of his seven titles with the Silver Arrows, as he now looks to roll the dice on a Ferrari resurgence next season to obtain an elusive eighth.
Despite his previous success, Hamilton is all too aware that there will be a period of adaptation that will have its own hurdles.
“It’s going to be new," he told Sky Sports' Martin Brundle. "It’s also daunting because it’s new territory, it’s a new experience, and will be a challenge. But, you know, I love challenges.
“I expect it to be massively different. I mean, the two teams I’ve been with have been British teams. So I’m going into a completely different culture in Italy.
“If you think about us Brits," he continued. "We’re very quiet and more calm when you have success, when you have difficult days, everyone’s kind of more chilled out whereas Italians are much more emotional.
“It’s a much different culture. I don’t truly know what to expect but I have raced in Italy, so I expect it to be a huge amount different but special and unique in some ways.”