The combination has been fruitful in a way no other pairing in the sport's history has, winning six drivers' titles and eight constructors' championships together.
However, since the inception of the 2022 regulations, Mercedes have not been able to get the measure of Red Bull, and now sit fourth in the standings.
Speaking on the Sky Sports F1 podcast, pundit and ex-driver Naomi Schiff questioned if the iconic pairing will make it through the remainder of the season.
“You could see that already in Monaco there was some weird body language and sort of Lewis saying that he was not going to out-qualify George for the rest of the season.
“So I don't know if there's also a whole new layer of a psychological aspect that's coming in with essentially what is like a divorce between Lewis and the team, and it's going to happen throughout the season," Schiff said.
Having previously won in every season he had competed in F1 since his rookie year of 2007, Hamilton has been titleless since late 2021, and has not stepped onto a grand prix podium yet in 2024.
Team-mate George Russell also lambasted his own errors as he finished third, but had at least managed to take pole the previous day, when Hamilton could only manage seventh in qualifying.
“Inevitably, he's going to start being left out of important meetings," Schiff added.
"New parts - George is going to be the preference for the team in terms of that but obviously he's also ahead of him in the championship, so that's the case anyway.
“But all these sorts of things are going to plant a little bit of a layer of doubt. Both in the team's head and Lewis' head of ‘What game are they playing?’, [and Mercedes wondering] ‘Has Lewis checked out, is he still on board?’.
“I know that there's a sentiment from Mercedes and Lewis that they want to end this [relationship] on a high. I think they both really feel that way."
Despite the uneasy situation both parties find themselves in, the target for team and driver will surely be to see off an iconic partnership in the finest style with at least one more victory to add to their 82 wins together.
"There's so much respect between the team and the driver, but the reality of it all is, when that doubt starts to creep in, can you maintain that relationship with the team?” Schiff asked.
Hamilton has 15 races left with the Brackley outfit to find that happy ending which so often does not materialise in sport. Having broken countless records together, it remains to be seen whether Hamilton and Mercedes can buck one more trend.