The Monegasque driver had a four-tenth advantage over Max Verstappen, who struggled to complete a qualifying simulation together across either of the practice sessions having damaged the floor of his car during the morning runs.
The wind appeared to play less havoc for the drivers in the late afternoon, with less mistakes over the course of FP2 in a session that only featured 19 drivers with Alex Albon's FP1 dramas leaving Williams with a huge headache for the rest of the weekend.
Both Aston Martins surprised with both cars inside the top five, including Lance Stroll ahead of his team-mate Fernando Alonso in fourth.
Mercedes’ Lewis Hamilton continued to struggle, ending Friday’s running in a shocking 18th place and leaving the Silver Arrows with plenty of work to do overnight.
Lando Norris set the early pace in FP1 for McLaren, closely followed by Max Verstappen who had a scruffy session in second.
Just two tenths of a second separated the top nine cars as Lewis Hamilton struggled with multiple moments which left him questioning whether he had broken his floor.
Most drivers struggled down the road at the tricky turn ten, with the likes of Valtteri Bottas, George Russell and Fernando Alonso all taking trips through the runoff area.