It took until lap six for the first major action of the race, with a DRS train up and down the field preventing there from being much in the way of battling.
The Canadian driver lost control of his car at turn 22 after touching the wall, spearing into the barrier at high speed.
He became the second retirement from the race after Pierre Gasly retired on lap two with a gearbox issue for Alpine - continuing the team's miserable start to the season.
It's also a second consecutive weekend with a problem for Stroll, who was collected by Nico Hulkenberg at the Bahrain Grand Prix.
Criticisms from fans who believe he should be replaced at Aston Martin will only be getting louder as he continues to find himself wrapped up in incidents.