Ferrari's Charles Leclerc, fresh from the disappointment of a post-race disqualification last weekend, managed to post a time good enough for third, ahead of Valtteri Bottas in the Alfa Romeo.
Red Bull show their strength
Most of the fans at the Autodromo Hermanos Rodriguez will be pleased to hear that Red Bull are once again on top, as they hope that their home-boy Perez can give them a weekend to remember.
The Mexican has struggled to keep up with his world champion team-mate so far this season, but this particular race would be the ideal time for him to pull a third race win of the season out of the bag, with Saturday qualifying being crucial to his chances.
Those particular issues in qualifying in Austin didn't make too much of a difference, however, as Verstappen cruised to victory in both the sprint race, and Sunday's main race.
However, a stronger start to this weekend will give the three-time world champion even more confidence that he can claim a 31st career pole position on Saturday.
Having been off the pace in FP1 with the pairing of Lewis Hamilton and Formula 1 rookie Frederik Vesti, Toto Wolff had been upbeat about the weekend, suggesting that Hamilton 'would have been P2/P3' without a small mistake he made on his quickest lap.
However, with George Russell rejoining his seven-time world champion team-mate, the times didn't seem to improve. Hamilton could only manage seventh, 0.338 seconds off the pace of Verstappen, whilst Russell was down in 10th.
They will need to seriously improve if they want to challenge the likes of McLaren, Ferrari and, of course, Red Bull for pole position on Saturday.
Rain arrives in Mexico City
Early on in the session, a small amount of rain fell on the circuit, providing a slightly more greasy surface than drivers and teams were expecting.
Due to the very high temperatures and high altitude at the track, the rain didn't cause too many problems and nobody decided to switch onto intermediate or wet tyres, but it did lead to a scare for Lando Norris, who experienced a bit of a slide.
The rain did then return towards the end of the session too, meaning that some teams' long runs were affected slightly.